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Choline and its metabolites are differently associated with cardiometabolic risk factors, history of cardiovascular disease, and MRI-documented cerebrovascular disease in older adults

surrogate endpoints (weight, HbA1c) are not hard outcomes

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46 By 2021, semaglutide (Wegovy , Novo Nordisk) administered by subcutaneous injection was also approved by the US FDA as an obesity treatment (Table 1)

For complex or ongoing treatments, especially those involving injectable medications, working with a provider who offers regular follow-ups and personalized monitoring is generally preferable